The 10th iHuman Forum

October 31 to November 1, 2025

L Building Auditorium, ShanghaiTech University

The 10th iHuman Forum

October 31 to November 1, 2025

L Building Auditorium, ShanghaiTech University


About the Event

The 10th iHuman Forum, organized by the iHuman Institute at ShanghaiTech University, will be held at the ShanghaiTech University from October 31 to November 1, 2025.

With the strong support of ShanghaiTech University, the iHuman Forum has been successfully held nine times and has become a globally recognized academic platform in cutting-edge GPCR science and drug discovery. Each year, it attracts leading scientists and scholars, as well as professionals from the biopharmaceutical industry, working at the forefront of membrane proteins, chemical biology, and computational biology. Notably, in 2024, the iHuman Forum was, for the first time, included in the 17th Pujiang Innovation Forum, further solidifying its role as a flagship annual academic event of ShanghaiTech University.

This year’s forum will center on four major themes: Membrane Protein Structure & Function, Chemical Biology & Drug Discovery, In Situ Structural Biology, and Computational Structure Biology & Pharmacology. We warmly welcome scientists from research institutions, universities, and the biopharmaceutical industry to participate and join the conversation on innovation and discovery.


Organizing Committee

Hosted by:

iHuman Institute, ShanghaiTech University

Conference Chair:

Raymond Stevens, LIU Zhi-Jie, Kurt Wüthrich, Wolfgang Baumeister

Organizing Committee:

CHENG Jianjun, HUA Tian, LIU Zhi-Jie, SHAN Yibing, SHUI Wenqing, Yuichi Sugiyama, XU Fei, ZHANG Xiaojie, ZHAO Suwen, ZHONG Guisheng


Program

Session I|Membrane Protein Structure & Function|Chairs: XU Fei & HUA Tian
8:40-8:50Opening Remarks
8:50-8:55Photo
8:55-9:30PLENARY | Positive cooperativity enhances coupling of two G proteins to a GPCR dimerChris TateMRC Laboratory of Molecular Biology
9:30-9:45Coffee Break
9:45-10:10Structural Insights into Compartmentalization in Human Sperm雷鸣
LEI Ming
Shanghai Jiao Tong University School of Medicine
10:10-10:35Orphan GPCRs, Chronic Liver Diseases and Itch: from bench to bedside李毓龙
LI Yulong
Peking University
10:35-11:00GPCR signaling in islet homeostasis and metabolism于晓
YU Xiao
Shandong University
11:00-11:25Computational Protein Design for Immunotherapy and Immune Modulation杨为
YANG Wei
Shenzhen Medical Academy of Research and Translation
11:25-11:50Structure-guided design of a fast-acting antidepressant曹灿
CAO Can
University of Science and Technology of China
11:50-12:15Structural pharmacology studies on human taste receptors华甜
HUA Tian
ShanghaiTech University
12:15-13:30Lunch Break


Session II. Chemical Biology & Drug Discovery | Chairs: SHUI Wenqing & CHENG Jianjun
13:30-13:55Chronic Itch: From Mechanism to Drug Discovery雷晓光
LEI Xiaoguang
Peking University
13:55-14:20Peptidomimetics in GPCRs: from structural insights to clinical blockbusters王明伟
WANG Mingwei
Fudan University School of Basic Medical Sciences, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
14:20-14:45PELSA:the Broadly Applicable Proteomics Method for Identifying Ligand-Binding Proteins and Binding Sites in complex samples叶明亮
YE Mingliang
Dalian Institute of Chemical Physics, CAS
14:45-15:00Coffee Break
15:00-15:25PLENARY | Trends in GPCR drug discovery (online) David E. GloriamUniversity of Copenhagen
15:25-15:50Photo-crosslinking Platform for Discovering Molecular Glue Degrader and Expanding Target Space陈小华
CHEN Xiaohua
Shanghai Institute of Materia Medica, CAS
15:50-16:15Chemical Biology of Drugging the Undruggable Targets邓贤明
DENG Xianming
Xiamen University
16:15-16:40ABPP-CoDEL: A high-throughput screening platform for covalent ligand discovery周璐
ZHOU Lu
Fudan University
16:40-16:55Recent advances and applications for dual-beam microscopes in cryo-EMAlexander RigortThermo Fisher Scientific
16:55-17:10Developing Small Molecule Agonists of GLP-1R and Other Obesity-Related Peptide-Binding GPCRs吴凡
WU Fan
Structure Therapeutics
17:10-18:10Poster Session 
18:30-20:00Dinner


Session III|In Situ Structural Biology|Chairs:Wolfgang Baumeister & ZHANG Xiaojie
8:30-9:00PLENARY | Recent advances in molecular imaging of synapsesAxel BrungerHoward Hughes Medical Institute & Stanford University
9:00-9:30PLENARY | Discovering Chimallivirus biology with in-cell cryo-EMElizabeth VillaHoward Hughes Medical Institute & University of California - San Diego
9:30-10:00PLENARY | Conformational flexibility and molecular plasticity in herpesvirus entry and egressKay GrünewaldCentre for Structural Systems Biology; Leibniz Institute of Virology; Universität Hamburg
10:00-10:15Coffee Break
10:15-10:40Unveiling Molecular Crowding in situ with Cryo-ET郭强
GUO Qiang
Peking University
10:40-11:05The Development of CryoET Preprocessing Pipelines at Chan Zuckerberg Imaging InstituteShawn ZhengChan Zuckerberg Imaging Institute
11:05-11:30Structural basis of HA pairing on the Influenza viral surface李赛
LI Sai
Tsinghua University
11:30-11:55In situ architecture of epididymal epithelial cells and intercellular organelle reservoir by volume electron microscopy陈浩
CHEN Hao
Guangzhou Medical University
11:55-12:10Cryo-ET sample preparation and targeting for large volume samplesOda Helene SchiøtzMax Planck Institute of Biochemistry
12:10-12:25Cryo-ET in context: FIB-based sample preparation for multiscale cryo-imaging from elegans larvae to vertebrate ocular tissueChristoph KaiserMax Planck Institute of Biochemistry
12:25-14:00Lunch Break


Session IV|Computational Structural Biology & Pharmacology|Chairs: SHAN Yibing, Yuichi Sugiyama & ZHAO Suwen
14:00-14:25PLENARY | From One 'State Art' to Another 'State of A.R.T': Achieving Regulatory Trust in Moving PBPK Applications from Science to PracticeAmin Rostami-HodjeganManchester University
14:25-14:50PLENARY | The γ subunit rotation in F1-ATPase with atomistic molecular dynamics simulationsYuji SugitaRIKEN Pioneering Research Institute
14:50-15:15PLENARY | Computational approaches for making undruggable targets druggable来鲁华
LAI Luhua
Peking University
15:15-15:30Coffee Break
15:30-15:50Sequence-Based Predictions on Intrinsically Disordered Proteins: from Backbone Dynamics to Phase Separation周焕祥
ZHOU Huanxiang
University of Illinois at Chicago
15:50-16:10Decoding Adaptive Immune Responses using Machine LearningDaron StandleyThe University of Osaka 
16:10-16:30Exploring the Protein Universe via Highly Accurate Structure Predictions (online) Martin SteineggerSeoul National University
16:30-16:50Protein structure generation and sequence optimization龚海鹏
GONG Haipeng
Tsinghua University
16:50-17:10Decoding the Molecular Mechanisms of Valence Selectivity in Ca²⁺ Channels: A Computational Study宋晨
SONG Chen
Peking University
17:10-17:20Poster Awards & Volunteer Appreciation
17:20-17:30Closing Remarks


Speaker

(In alphabetical order by last name, Updating continuously)

Session ICAO CanUniversity of Science and Technology of China
HUA TianShanghaiTech University
LEI MingShanghai Jiao Tong University School of Medicine
LI YulongPeking University
Chris TateMRC Laboratory of Molecular Biology
YANG WeiShenzhen Medical Academy of Research and Translation
YU XiaoShandong University
Session IICHEN XiaohuaShanghai Institute of Materia Medica, CAS
DENG XianmingXiamen University
David E. GloriamUniversity of Copenhagen
LEI XiaoguangPeking University
WANG MingweiFudan University School of Basic Medical Sciences & Ruijin Hospital 
YE MingliangDalian Institute of Chemical Physics, CAS
ZHOU LuFudan University
Session IIIAxel BrungerHoward Hughes Medical Institute & Stanford University
CHEN HaoGuangzhou Medical University
Kay GrünewaldCentre for Structural Systems Biology & Leibniz Institute of Virology & Universität Hamburg
GUO QiangPeking University
Christoph KaiserMax Planck Institute of Biochemistry
LI SaiTsinghua University
Oda Helene SchiøtzMax Planck Institute of Biochemistry
Elizabeth VillaHoward Hughes Medical Institute & University of California - San Diego
Shawn ZhengChan Zuckerberg Imaging Institute
Session IVGONG HaipengTsinghua University
LAI LuhuaPeking University
Alexander RigortThermo Fisher Scientific
Amin Rostami-HodjeganManchester University
SONG ChenPeking University
Daron StandleyOsaka University
Martin SteineggerSeoul National University
Yuji SujitaRIKEN Pioneering Research Institute


Contact us

Contact Person: Dr. Feng (Ms.)

Phone: +86-21-2068 4420

Email: ihuman-forum@shanghaitech.edu.cn


Accommodation

本次会议不提供住宿预定,住宿及交通费用需自理,以下为会场附近酒店信息,如需请直接联系酒店。

雅乐轩酒店如意智慧酒店
上海市浦东新区海科路555号上海市浦东新区科苑路1500号
电话:+86-21-3816 8888 电话:+86-21-6165 1111 


旅笼温泉假日酒店张江智选假日酒店 
上海市浦东新区金科路4395号上海市浦东新区海科路777号
电话:+86-21-5832 0566电话:+86-21-6033 7888


上海浦东嘉里大酒店
上海市浦东新区花木路1388号
电话:+86-21-6169 8888